Ali RIŞVANLI | Ruslan SALIKOV

Article | 2023 | Applied Sciences-Basel13 ( 21 )

The therapeutic potential of Angelica ternata extract was tested against biofilm-associated fungi Candida albicans. Such an extract with a 1.896 ± 0.071 per 1 mL rutin content of flavonoids can reliably suppress the formation of biofilms of pathogenic yeast-like fungi up to 76.6. The herbal medicine has a significant effect on the initiation, adhesion, and development of biofilms. If the extract is added to a developed biofilm, it has a significant effect on the matrix. As a result, the “glue” between the cells is washed out and they are more easily washed away from the well of the microplate to which they are attached. In this case . . ., the optical density of the biofilm is halved (50.5). Keywords: candida albicans; biofilms; extracellular matrix; angelica ternate; flavonoid More less